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Goto M, Mukoyama M, Sugawara A, Suganami T, Kasahara M, Yahata K, Makino H, Suga S, Tanaka I, Nakao K
Abstract Phosphodiesterase 1B (PDE1B) and phosphodiesterase 10A (PDE10A), members of the phosphodiesterase superfamily, are responsible for cyclic nucleotide hydrolysis, thereby regulating key intracellular signaling pathways such as cAMP response element-binding protein (CREB) activation and brain-derived neurotrophic factor (BDNF) gene transcription
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Raynaud's Phenomenon And Vasospasm Raynaud's phenomenon involves episodic vasospasm (sudden narrowing) of small arteries in response to cold or stress, typically affecting fingers and toes
10.1002/rcm.9205 187 ZhangH.WangZ